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AEM Accepts, published online ahead of print on 3 October 2008
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Appl. Environ. Microbiol. doi:10.1128/AEM.01019-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Secreting insulinotropic proteins from commensal bacteria: rewiring the gut to treat diabetes

Faping Duan, Katherine L. Curtis, and John C. March*

Department of Biological and Environmental Engineering, Cornell University, Ithaca, NY 14853

* To whom correspondence should be addressed. Email: jcm224{at}cornell.edu.


  Abstract

Here we show that commensal bacteria can stimulate intestinal epithelia cells to secrete insulin in response to glucose. Commensal strains were engineered to secrete the insulinotropic proteins GLP-1 and PDX-1. Epithelia stimulated by engineered strains and glucose secreted up to 1 ng mL-1 of insulin with no significant background secretion.






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