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Applied and Environmental Microbiology, September 1998, p. 3530-3532, Vol. 64, No. 9
0099-2240/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Influence of Lipid Composition on Pediocin PA-1 Binding to Phospholipid Vesiclesdagger

Yuhuan Chen, Richard D. Ludescher, and Thomas J. Montville*

Department of Food Science, Cook College, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901

Received 15 April 1998/Accepted 22 June 1998

Pediocin PA-1 bound to anionic lipid vesicles with saturated or unsaturated fatty acid chains in a lipid concentration-dependent fashion. Little change in binding parameters was observed for zwitterionic lipid vesicles. Decreasing the anionic lipid content of the vesicles gave a higher relative dissociation constant for the peptide-lipid interactions and further supports the electrostatic interaction model of binding.

* Corresponding author. Mailing address: Department of Food Science, Cook College, Rutgers, The State University of New Jersey, 65 Dudley Rd., New Brunswick, NJ 08901. Phone: (732) 932-9611, ext. 201. Fax: (732) 932-6776. E-mail: montville{at}aesop.rutgers.edu.

dagger Report D-10131-1-98 of the New Jersey Agricultural Experiment Station.

Applied and Environmental Microbiology, September 1998, p. 3530-3532, Vol. 64, No. 9
0099-2240/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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