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Appl. Environ. Microbiol., 03 1995, 941-943, Vol 61, No. 3
Copyright © 1995, American Society for Microbiology

Isolation and characterization of a cytotoxic metabolite of Talaromyces bacillosporus

K Ishii, T Itoh, K Kobayashi, Y Horie and Y Ueno
Laboratory of Toxicology and Microbial Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan.

A cytotoxic metabolite, talarotoxin, was isolated from a fungus, Talaromyces bacillosporus IFO 8397, cultured on rice. The structure of the toxin was elucidated and found to contain a pyrrolizidinedione connected with a trans delta 1-octalin through a conjugated triene.




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Copyright © 1995 by the American Society for Microbiology. All rights reserved.