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Appl Environ Microbiol. 1992 December; 58(12): 3879-3882

Biphenomycin A production by a mixed culture.

M Ezaki, M Iwami, M Yamashita, T Komori, K Umehara and H Imanaka

Exploratory Research Laboratory, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.

ABSTRACT

Production of biphenomycin A by Streptomyces griseorubiginosus 43708 was stimulated by a mixed culture with a partner strain, Pseudomonas maltophilia 1928. This stimulatory effect on biphenomycin A accumulation by the mixed culture was caused by the enzyme activity which strain 1928 possessed. It is suggested that in a mixed culture strain 43708 produces a precursor of biphenomycin A in culture broth and that strain 1928 converts the precursor to biphenomycin A.

Appl Environ Microbiol. 1992 December; 58(12): 3879-3882






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