This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Johnson, A. C. Articles by Wood, M. Search for Related Content PubMed PubMed Citation Articles by Johnson, A. C. Articles by Wood, M. Agricola Articles by Johnson, A. C. Articles by Wood, M.

Next Article 

Appl Environ Microbiol. 1990 December; 56(12): 3629-3633
Copyright © 1990, American Society for Microbiology. All Rights Reserved.

DNA, a Possible Site of Action of Aluminum in Rhizobium spp

Department of Soil Science, The University of Reading, London Road, Reading RG1 5AQ, United Kingdom

ABSTRACT

Al was found to penetrate the cell envelopes of both sensitive and tolerant Rhizobium strains and bind to DNA in vivo. Despite causing a reduction in viability, Al stimulated DNA synthesis in the sensitive strain, which suggested that an excision repair mechanism was operating. The Al-stimulated DNA synthesis was reduced by the simultaneous addition of chloramphenicol. In contrast to the sensitive strain, DNA synthesis was unaffected by Al binding to DNA in the tolerant strain. It is proposed that Al enters the cell and binds to the DNA helix, increasing stabilization and preventing successful replication. Different repair mechanisms appear to operate in response to Al in tolerant and sensitive strains.

^* Corresponding author.

This article has been cited by other articles:

• Avis, T. J., Michaud, M., Tweddell, R. J. (2007). Role of Lipid Composition and Lipid Peroxidation in the Sensitivity of Fungal Plant Pathogens to Aluminum Chloride and Sodium Metabisulfite. Appl. Environ. Microbiol. 73: 2820-2824 [Abstract] [Full Text]  
• Yaganza, E.-S., Rioux, D., Simard, M., Arul, J., Tweddell, R. J. (2004). Ultrastructural Alterations of Erwinia carotovora subsp. atroseptica Caused by Treatment with Aluminum Chloride and Sodium Metabisulfite. Appl. Environ. Microbiol. 70: 6800-6808 [Abstract] [Full Text]  
• Nanba, K., King, G. M. (2000). Response of Atmospheric Methane Consumption by Maine Forest Soils to Exogenous Aluminum Salts. Appl. Environ. Microbiol. 66: 3674-3679 [Abstract] [Full Text]  
• Zahran, H. H. (1999). Rhizobium-Legume Symbiosis and Nitrogen Fixation under Severe Conditions and in an Arid Climate. Microbiol. Mol. Biol. Rev. 63: 968-989 [Abstract] [Full Text]