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Appl Environ Microbiol. 1990 November; 56(11): 3595-3597
Copyright © 1990, American Society for Microbiology. All Rights Reserved.

Stereospecific Reduction of Ethyl 2' -Ketopantothenate to Ethyl D-(+)-Pantothenate with Microbial Cells as a Catalyst

Department of Agricultural Chemistry, Kyoto University, Kitashirakawa, Sakyo ku, Kyoto 606, Japan

ABSTRACT

A novel enzymatic process for the synthesis of D-(+)-pantothenic acid through the asymmetric reduction of the 2' -ketopantothenate ester is described. Candida macedoniensis AKU 4588 was found to convert ethyl 2' -ketopantothenate (80 mg/ml) almost specifically to ethyl D-(+)-pantothenate (>98% enantiomeric excess), with a molar yield of 97.2%.

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