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Appl Environ Microbiol. 1971 August; 22(2): 229-232
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Changes in Escherichia coli Associated with Acquired Tolerance for Quaternary Ammonium Compounds 1

R. B. Maxcy, N. P. Tiwari and P. R. Soprey2

Department of Food Science and Technology, University of Nebraska, Lincoln, Nebraska 68503

ABSTRACT

Acquired tolerance for a quaternary ammonium compound produced a tolerance for a similar compound. Tolerance was associated with the structure and the extent of adsorption of the compound. Morphological changes and resistance to disruption by pressure and by sonic treatment accompanied the development of tolerance. An otherwise weakened culture evolved with the acquisition of tolerance. The maximum obtainable viable population density of tolerant cells in growth medium was approximately 5% of that obtained in the parent culture. Tolerant cultures died off more rapidly in the original growth medium as well as when washed cell suspensions were stored at 5 C. Since acquired tolerance was associated with an otherwise weakened culture, the occurrence of the tolerant cells to limit the efficacy of quaternary ammonium compounds in sanitation operations is highly unlikely.

FOOTNOTES

2 Present address: Department of Microbiology, The Medical School, Northwestern University, Chicago, Ill.

1 Published with the approval of the Director as paper no. 2455, Journal Series, Nebraska Agricultural Experiment Station, Lincoln. Research reported was conducted under project number 16-8.

Appl Environ Microbiol. 1971 August; 22(2): 229-232
Copyright © 1971 American Society for Microbiology. All Rights Reserved.





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Copyright © 1971 by the American Society for Microbiology. All rights reserved.