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Appl Environ Microbiol. 1971 August; 22(2): 153-156
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Stimulative Effect of Elemental Sulfur on Siomycin Production by Streptomyces sioyaensis

Sigeo Yagi, Seiji Kitai and Toshiaki Kimura

Shionogi Research Laboratory, Shionogi & Co., Ltd., Fukushima-ku, Osaka, Japan

ABSTRACT

The addition of elemental sulfur to the fermentation of Streptomyces sioyaensis in a soybean meal medium resulted in a three- to fourfold increase of siomycin. Further experiments on the effect of elemental sulfur during fermentation suggest that one of the key steps stimulating siomycin synthesis is the utilization of thiosulfate, which accumulates in the medium as the result of the oxidation of elemental sulfur.

Appl Environ Microbiol. 1971 August; 22(2): 153-156
Copyright © 1971 American Society for Microbiology. All Rights Reserved.





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Copyright © 1971 by the American Society for Microbiology. All rights reserved.