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Appl Environ Microbiol. 1971 July; 22(1): 93-95
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

In Vitro Sensitivity of Torulopsis glabrata to Amphotericin B, 5-Fluorocytosine, and Clotrimazole (Bay 5097)

Departments of Medicine and Pediatrics, University of Colorado Medical Center, Denver, Colorado 80220

ABSTRACT

Thirty-five strains of Torulopsis glabrata were tested by a tube dilution method for their susceptibility to amphotericin B, 5-fluorocytosine, and clotrimazole (Bay 5097). Amphotericin B was the most active in vitro, inhibiting all strains at a concentration of 1 µg/ml and killing all strains at 2 µg/ml. 5-Fluorocytosine inhibited over 80% of strains at 0.24 µg/ml, but three strains required 7.8 µg/ml for killing. A concentration of 2 µg of clotrimazole per ml inhibited less than 50% of strains, and 8 µg/ml killed only 10% of strains. Most strains of T. glabrata were killed by therapeutically achievable concentrations of amphotericin B and 5-fluorocytosine, but not clotrimazole.

¹ Present address: Montreal Children's Hospital, Montreal 108, Quebec, Canada.