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Appl Environ Microbiol. 1971 July; 22(1): 23-25
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

In Vitro Susceptibility of Atypical Mycobacteria To Rifampin

Infectious Disease Service, New England Medical Center Hospitals, and the Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02111

ABSTRACT

Atypical mycobacteria (209 strains) were examined for susceptibility to rifampin by the proportion method by using Middlebrook 7H-10 agar. All strains of Mycobacterium kansasii and tap-water scotochromogens were inhibited by 0.25 to 1 µg of the drug per ml. Seventy-six per cent of M. scrofulaceum and 61% of M. intracellulare strains were susceptible to 4 µg/ml or less; 5% of the former and 8% of the latter were resistant to 16 µg/ml. All strains of M. gastri and M. triviale and most strains of M. terrae were sensitive to 1 to 4 µg/ml. Two strains of M. borstelense were both inhibited by 8 µg/ml. Nearly all strains of M. fortuitum were resistant to the drug. The results of this study suggest that rifampin may be a valuable agent for the treatment of many atypical mycobacterial infections.