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Appl Environ Microbiol. 1971 July; 22(1): 106-109
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Effect of Antibiotics on Staphylococcal Hemolysin Production

Division of Microbiology and Epidemiology, Department of Pathology, The Bronx-Lebanon Hospital Center, Bronx, New York 10456
Department of Microbiology, The Mount Sinai School of Medicine, New York, New York 10029

ABSTRACT

Thirty-seven per cent of 126 strains of Staphylococcus aureus, when tested on sheep blood-agar with sensitivity discs containing cephalothin, carbenicillin, oxacillin, penicillin, and cycloserine, produced rings of ß-hemolysis surrounding zones of inhibition of bacterial growth. Each strain capable of producing a ring of ß-hemolysis did so with at least two of the mentioned antibiotics. None of the other 15 antibiotics tested was associated with a ring of ß-hemolysis surrounding any of the zones of inhibition. It appears, therefore, that the ß-hemolysis observed was produced by certain strains of S. aureus only in association with certain antibiotics.