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Appl Environ Microbiol. 1971 May; 21(5): 841-843
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Production of Substituted L-Tryptophans by Fermentation ¹

Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46206

ABSTRACT

Claviceps purpurea has been shown to produce extracellular L-tryptophan from indole in stirred fermentors. The substrate specificity of this conversion was investigated by using substituted indoles, anthranilic acid, and 4-chloro-anthranilic acid. Addition of 2-, 4-, 5-, 6-, and 7-methyl indole or 6-chloroindole to C. purpurea C1M produced the corresponding substituted L-tryptophan. In contrast, addition of l-methyl, 6-trifluoromethyl, 6-nitro-, or 4-benzyloxy-substituted indoles, or anthranilic and 4-chloroanthranilic acids did not produce detectable amounts of the corresponding tryptophan.

¹ Presented at the 70th Annual Meeting of the American Society for Microbiology, Boston, Mass., 26 April to 1 May 1970.