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Appl Environ Microbiol. 1971 April; 21(4): 676-679
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Effect of Relative Humidity on Dynamic Aerosols of Adenovirus 12

Department of Veterinary Pathology, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio 43210

ABSTRACT

Dynamic aerosols of adenovirus 12 were generated in the same Henderson apparatus under conditions of high, medium, and low relative humidity. High relative humidities resulted in more recovery of adenovirus 12 from aerosols and lungs of newborn Syrian hamsters. At 89, 51, and 32% relative humidity, the total infectious virus recovered from a 20-min aerosol was 10^6.7, 10^6.0, and 10^4.3 TCD₅₀, respectively. Hamsters exposed to these 20-min aerosols retained measured lung doses of 10^3.0, 10^2.4, and 10^1.0 TCD₅₀, respectively. The measured retained lung doses were compared to calculated inhaled lung doses based on both total virus aerosolized and total virus recovery from the aerosols.