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Appl Environ Microbiol. 1971 April; 21(4): 580-584
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Effect of Chlorite-Oxidized Oxyamylose on Influenza Virus Infection in Mice

Rega Institute for Medical Research, University of Leuven, 3000 Leuven, Belgium

ABSTRACT

Intraperitoneally administered chlorite-oxidized oxyamylose (COAM) provided protection of mice against intranasal infection with several influenza virus strains. Treated animals invariably showed a reduced consolidation of the lungs and, in the case of infection with lethal strains of virus, also a delay in mortality. With a small dose of influenza A/PR8 virus, an increase in final survival rate could be observed. The effect of COAM on influenza virus infection lasted for at least 4 to 8 days. Inhibition of lung consolidation was not paralleled by a decrease in virus multiplication in the lung. The significance of this finding in relation to the mechanism of the antiviral action of COAM is discussed.

¹ "Bevoegdverklaard navorser" of the Belgian N.F.W.O.

² Assistant of the University of Lovanium, Kinshasa, Democratic Republic of Congo, and fellow of the Belgian O.C.D.