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Appl Environ Microbiol. 1970 July; 20(1): 6-10
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

Australia Antigen in a Closed Adult Population Monitored for Serum Glutamic Oxalacetic Transaminase

Microbiological Research Section, Cutter Laboratories, Berkeley, California 94710

ABSTRACT

A study of the presence of Australia antigen (Au/SH) was conducted over a period of 21 weeks among volunteer plasma donors living in a prison and being monitored for serum glutamic oxalacetic transaminase (SGOT). A good correlation was observed between the level of SGOT and presence of Au/SH, the latter being present in 33% of donors with SGOT values higher than 101 Karmen units and in 12% of those with SGOT values of 41 to 100 units. Furthermore, none of the 87 donors with all SGOT values below 40 was found positive for Au/SH. It should be noted, however, that single specimens only were tested from 72 of the 87 individuals. Au/SH was detected with equivalent efficiency by both agar gel precipitation and complement fixation procedures. Implications of these findings in the prognostication of hepatitis carrier state are discussed.