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Appl Environ Microbiol. 1970 June; 19(6): 955-959
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

Amphotericin B Serum Concentrations During Therapy 1

Branch T. Fields Jr.2, Joseph H. Bates and Robert S. Abernathy

Department of Medicine, University of Arkansas Medical Center and Veterans Administration Hospital, Little Rock, Arkansas 72205

ABSTRACT

Therapeutic outcome of patients being treated for systemic mycoses with amphotericin B is possibly related to the serum concentrations of this drug that are produced in these patients. Because current data are conflicting, the magnitude of these concentrations was restudied by using a bioassay which gave precise and accurate results. The highest of 155 serum concentrations was 2.01 µg/ml. Mean concentrations were 1.21, 0.62, and 0.32 µg/ml, at 1, 18, and 42 hr, respectively, after intravenous infusion of amphotericin B. This drug was detected in serum 7 weeks after completion of treatment, but it could not be detected 13 weeks after treatment. Drug levels did not appreciably decrease in serum stored for 8 to 9 months at – 10 C. Unequal serum content in assay tubes and measurement of assay turbidity by visual inspection may explain previously reported amphotericin B levels of 3.0 to 12.5 µg/ml.

FOOTNOTES

2 Present address: Wilford Hall USAF Medical Center, Lackland Air Force Base, Tex. 78236.

1 Presented in part before the 28th Veterans Administration-Armed Forces Pulmonary Disease Research Conference, Cleveland, Ohio, 21 January 1969.

Appl Environ Microbiol. 1970 June; 19(6): 955-959
Copyright © 1970 American Society for Microbiology. All Rights Reserved.





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