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Appl Environ Microbiol. 1970 May; 19(5): 837-841
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

Fowl Cholera Immunization in Turkeys

I. Efficacy of Various Cell Fractions of Pasteurella multocida as Vaccines¹

Department of Medical Microbiology, and Department of Medicine and Surgery, School of Veterinary Medicine, University of Georgia, Athens, Georgia 30601

ABSTRACT

Cell fractions of Pastuerella multocida (P-1059) were tested as vaccines against fowl cholera in turkeys. These fractions were culture filtrate, cell wall, and cytoplasm. A second culture filtrate preparation made from cells grown on blood-agar rather than the standard medium was also tested along with a "combination" preparation made by recombination of the cell fractions. Each preparation was tested in three vehicles: saline, alum (0.5%), and Freund Incomplete Adjuvant (50%). The turkeys vaccinated with these preparations were challenged by exposure to an experimental epornitic of fowl cholera. The combination fraction appeared to be the most promising vaccine when compared to the protective action of the commercial bacterin included in the test as a positive control.

¹ Paper no. 764, Institute of Comparative Medicine, University of Georgia, Athens, Ga. 30601.