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Appl Environ Microbiol. 1970 April; 19(4): 613-617
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

Production of Rubratoxin B by Penicillium purpurogenum Stoll

National Institute of Hygienic Sciences, Kamiyoga-1-chome, Setagaya-ku, Tokyo
Institute of Medical Science, the University of Tokyo, Shirokanedai, Minato-ku, Tokyo

ABSTRACT

Culture filtrates and chloroform extracts from Penicillium purpurogenum isolated from foodstuffs were subjected to preliminary survey for toxic effects on HeLa cells and mice. The toxic metabolite was isolated in a crystalline form from P. purpurogenum and was identified as rubratoxin B. Pathological findings observed in HeLa cells and mice treated with the metabolite are briefly described.