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Appl Environ Microbiol. 1970 April; 19(4): 608-612
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

Formation of Hydrogen Peroxide by Group N Streptococci and Its Effect on Their Growth and Metabolism

Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria 3052, Australia
Division of Dairy Research, Commonwealth Scientific and Industrial Research Organization, Melbourne, Victoria 3190, Australia

ABSTRACT

The formation of hydrogen peroxide by group N streptococci was found to occur through the action of a reduced nicotinamide adenine dinucleotide (NADH) oxidase which catalyzed the oxidation of NADH by molecular oxygen. The enzyme was activated by flavine adenine dinucleotide. Whereas some of the hydrogen peroxide formed was removed through the action of an NADH peroxidase, sufficient accumulated in media to inhibit the growth, respiration, and viability of these organisms. The amount of hydrogen peroxide which accumulated varied among strains, and this variation could be related to differences in the properties of the NADH oxidase present.

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