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Appl Environ Microbiol. 1970 April; 19(4): 589-593
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

Regression Curve Analysis of Cephalosporin Activity

Section of Microbiology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55901

ABSTRACT

Regression lines were calculated for cephalothin, cephalexin, and cephaloridine by relating zone diameters of inhibition to minimal inhibitory concentrations (MIC) obtained in Mueller-Hinton agar and in Trypticase Soy Agar. A regression line was calculated for cephaloglycin by obtaining MIC values in Trypticase Soy Agar at pH 6.6. Regression lines calculated from MIC values in Mueller-Hinton agar were practically superimposable on those based on MIC values in Trypticase Soy Agar. Organisms susceptible by disc testing to cephalothin were usually susceptible to cephalexin and cephaloridine.