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Appl Environ Microbiol. 1970 April; 19(4): 583-585
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

Pulmonary Absorption and Retention of Kanamycin After Repeated Inhalation Administration of Kanamycin Aerosol

Richard H. Teske and Stephen B. Miller

Hill Top Research, Inc., Miamiville, Ohio

ABSTRACT

The absorption and retention of kanamycin by the pulmonary system was evaluated after aerosol administration to rats. Tissue level concentrations of the drug were assayed by the agar-plate bioassay method. Mean concentrations of 6.58 µg/g and 3.52 µg/g were found in the lung and kidney homogenates, respectively, 26 hr after the final exposure period. No detectable level was found in the plasma.

Appl Environ Microbiol. 1970 April; 19(4): 583-585
Copyright © 1970 American Society for Microbiology. All Rights Reserved.





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Copyright © 1970 by the American Society for Microbiology. All rights reserved.