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Appl Environ Microbiol. 1970 March; 19(3): 455-457
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

Effect of Temperature on Radiosensitivity of Newcastle Disease Virus ¹

Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

ABSTRACT

Newcastle disease virus was irradiated at temperatures ranging from 2.2 to 60 C. An interaction between the thermal and ionizing energy was observed in the temperature region of 49 to 60 C. At 2.2 C, the hemagglutinin was considerably more radioresistant than the infectivity property. It is believed that radiation inactivation of Newcastle disease virus infectivity at low temperatures was due to nucleic acid degradation and at higher temperatures was due to protein denaturation.

² Present address: Department of Microbiology, University of New Hampshire, Durham, N. H. 03824.

¹ This is contribution no. 1547 from the Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Mass. 02139.