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Appl Environ Microbiol. 1970 February; 19(2): 314-316
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

Pathogenicity of Clostridium perfringens for Germ-Free Guinea Pigs After Oral Ingestion

Laboratory of Microbial Immunity, and Laboratory of Bacterial Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

ABSTRACT

Germ-free guinea pigs died with signs and lesions of acute enterotoxemia after oral ingestion of C. perfringens types B, C, D, and E. The signs and lesions observed resembled those seen in acute enterotoxemia of sheep and cattle and the naturally occurring disease seen in "ex-germ-free" guinea pigs. C. perfringens type A was found to be innocuous. Conventional guinea pigs did not become ill after ingestion of any of the five toxigenic types.

¹ Present address: Section on Infectious Diseases, Perinatal Research Branch, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Md. 20014.

² Present address: Department of Microbiology and Public Health, Michigan State University, East Lansing, Mich. 48823.