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Appl Environ Microbiol. 1970 February; 19(2): 264-267
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

Procedures for the Assay of Carbenicillin in Body Fluids

Beecham Research Laboratories, Brockham Park, Betchworth, Surrey, England

ABSTRACT

The assay of carbenicillin in clinical specimens is complicated by the fact that carbenicillin also contains a small amount of benzylpenicillin, thereby precluding the use of conventional penicillin assay organisms. This report gives details of a microbiological assay method involving the use of a strain of Pseudomonas aeruginosa which is very sensitive to carbenicillin but insensitive to benzylpenicillin. The outline of a microassay method with this organism is presented, and a method for the assay of specimens containing mixtures of carbenicillin and other antibiotics is described.

¹ Present address: Pfizer, Ltd., Richborough Plant, Sandwich, Kent, England.