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Appl Environ Microbiol. 1970 February; 19(2): 259-263
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

In Vitro Antibacterial Activity of Minocycline and Effect of Agar Medium Utilized in Its Susceptibility Testing

Department of Microbiology and Division of Infectious Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55901

ABSTRACT

The in vitro activity of minocycline against 1,028 bacterial strains was determined in parallel in Mueller Hinton Agar and Trypticase Soy Agar. The broad antibacterial effect of minocycline against gram-positive cocci and gram-negative bacilli is confirmed. Minimal inhibitory concentrations for gram-positive bacteria in Mueller Hinton Agar were at least twofold less than in Trypticase Soy Agar. Minimal inhibitory concentrations for gram-negative bacilli in Mueller Hinton Agar were usually fourfold less than in Trypticase Soy Agar.