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Appl Environ Microbiol. 1970 February; 19(2): 250-253
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

Agglutinin Response of Rabbits to Combined Pasteurella tularensis-Brucella abortus Vaccination ¹

Biological Sciences Laboratories, Department of the Army, Fort Detrick, Frederick, Maryland 21701

ABSTRACT

A schedule was developed for the simultaneous production of a Pasteurella tularensis-Brucella abortus antiserum in rabbits. Three doses of 10⁸ viable P. tularensis LVS organisms were given intravenously at weekly intervals. One day prior to the final dose of P. tularensis, the rabbits received 10⁹ viable cells of B. abortus strain 19 intravenously. The use of live vaccines, administered in this sequence, resulted in high agglutinin titers within 3 weeks. The maximal agglutinin titer to either organism was observed 1 week after the final injection.

¹ In conducting the research reported herein, the investigator adhered to "Guide for Laboratory Animal Facilities and Care" established by the Committee on the Guide for Laboratory Animal Facilities and Care by the Institute of Laboratory Animal Resources NAS-NRC.