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Appl Environ Microbiol. 1970 January; 19(1): 96-99
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

Inactivation of Vesicular Stomatitis Virus by Disinfectants

Diagnostic Services, Animal Health Division, National Animal Disease Laboratory, Ames, Iowa

ABSTRACT

Twenty-four chemical disinfectants considered to be viricidal were tested. Ten disinfectants were not viricidal for vesicular stomatitis virus within 10 min at 20 C when an LD₅₀ titer of 10^8.5 virus units per 0.1 ml were to be inactivated. Quantitative inactivation experiments were done with acid, alkaline, and a substituted phenolic disinfectant to determine the kinetics of the virus inactivation. Substituted phenolic disinfectants, halogens, and cresylic and hydrochloric acids were viricidal. Basic compounds such as lye and sodium metasilicate were not viricidal.