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Appl Environ Microbiol. 1970 January; 19(1): 196-198
Copyright © 1970 American Society for Microbiology. All Rights Reserved.

Growth of Venezuelan Equine Encephalomyelitis Virus in Human Diploid Cell Strain WI-38

Morton Reitman and Leonard Green

Immunology II Branch, MI Division, Fort Detrick, Frederick, Maryland 21701

ABSTRACT

We demonstrated that Venezuelan equine encephalomyelitis (VEE) virus replicated in and adapted rapidly to human diploid cell strain WI-38. Peak titers of approximately 109.8 mouse intracerebral 50% lethal doses were obtained at low passage levels in Eagles basal medium supplemented with calf serum. VEE virus replicated poorly in serum-free medium. Propagation of VEE virus was accompanied by the production of hemagglutinin and cytopathogenic effects.

Appl Environ Microbiol. 1970 January; 19(1): 196-198
Copyright © 1970 American Society for Microbiology. All Rights Reserved.





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Copyright © 1970 by the American Society for Microbiology. All rights reserved.