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Appl Environ Microbiol. 1968 August; 16(8): 1235-1239
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Clostridium perfringens Type A Infection of Ligated Intestinal Loops in Lambs

Microbiology Division, Food and Drug Directorate, Department of National Health and Welfare, Ottawa, Ontario, Canada
Animal Pathology Division, Health of Animals Branch, Department of Agriculture, Animal Diseases Research Institute (Western), Lethbridge, Alberta, Canada

ABSTRACT

Clostridium perfringens type A suspended in fresh medium was injected into ligated intestinal loops of lambs. Within 7 hr after inoculation, the fluid volume of the loops increased up to seven times. No significant accumulation of fluid occurred in loops receiving grown culture, culture supernatant fluid, or medium alone. -Antitoxin injected along with C. perfringens in fresh medium into intestinal loops did not prevent the accumulation of fluid. It is concluded that -toxin plays no major role in C. perfringens type A enteritis.