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Appl Environ Microbiol. 1968 August; 16(8): 1207-1210
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Effect of the Route of Inoculation on Antibody Formation in Guinea Pigs Immunized with Parainfluenza Virus Vaccines

Research Department, The National Drug Company, Swiftwater, Pennsylvania 18370

ABSTRACT

The efficiency of the intramuscular route of immunization of guinea pigs was compared with the intraperitoneal route when trivalent parainfluenza virus vaccine was employed as immunogen. When the routes of immunization were compared by effective dose 50, the intramuscular route was more effective. Likewise, a statistical evaluation of conversion rates and of titers revealed significantly higher values for the intramuscular than for the intraperitoneal route to all three components in two of the lots of vaccine tested.