This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Tamura, G. Articles by Arima, K. Search for Related Content PubMed Articles by Tamura, G. Articles by Arima, K. Agricola Articles by Tamura, G. Articles by Arima, K.

Next Article 

Appl Environ Microbiol. 1968 July; 16(7): 965-972
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Production of Mevalonic Acid by Fermentation

Laboratory of Microbiology, Department of Agricultural Chemistry, University of Tokyo, Bunkyo-ku, Tokyo, Japan

ABSTRACT

The purpose of this investigation was to select microorganisms that produce substantial quantities of mevalonic acid and to develop an economic fermentation process. To screen for mevalonic acid-producing microorganisms, it was necessary to improve the method for the quantitative determination of this acid. The biological assay was modified by shortening the incubation time and simplifying the procedure. The principle of the assay is based on the essential mevalonic acid requirement of the organism Lactobacillus heterohiochii for growth. Screening was carried out by selecting high mevalonic acid-producing organisms from various type cultures. Endomycopsis fibuliger was chosen for medium development studies, and 939 µg of mevalonic acid per ml was produced in the culture filtrate after modifications of medium and fermentation conditions.