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Appl Environ Microbiol. 1968 July; 16(7): 1056-1060
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Rapid Sulfonamide Disc Sensitivity Test for Meningococci

Epidemiology Program, National Communicable Disease Center, Public Health Service, Atlanta, Georgia 30333

ABSTRACT

Minimal inhibitory concentrations (MIC) of 90 strains of Neisseria meningitidis were determined by a plate dilution technique that employed twofold changes in concentrations of sulfadiazine. The geometric mean of three MIC determinations on each strain was correlated with inhibition zones produced by a 300-µg sulfathiazole disc. The linear relationship between the logarithm of the geometric mean MIC values and the zone diameters was highly significant. Strains were separated into sensitive and resistant populations by both test procedures. Quantitative criteria for interpreting the sensitivity of a strain by the disc test were established.

¹ Present address: Department of Medicine, University of Colorado Medical Center, Denver, Colo. 80220.