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Appl Environ Microbiol. 1968 July; 16(7): 1015-1018
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Serological Studies of the T and Tumor Antigens of the Oncogenic Simian Adenoviruses

Flow Laboratories Inc., Rockville, Maryland 20852
Southwest Foundation for Research and Education, San Antonio, Texas
National Institutes of Health, Bethesda, Maryland 20014

ABSTRACT

Tumor-specific antigens and antisera were prepared for eight of the oncogenic simian adenoviruses. Complement-fixation tests revealed three distinct serological subgroups. This grouping was maintained in studies of virus-infected cells (T antigens) although high titered preparations were obtained for only the major subgroup I. The current grouping is as follows: (I) SV1, SV11, SV25, SV33, SV34, SV38; (II) SV20, SV23; (III) SA 7. Antigens from each subgroup were rapidly inactivated at 56 C, and group II and III antigens were also markedly inactivated at 37 C. One of the tumors (SV1) also contained SV40 T antigen, suggesting origin from a simian adenovirus-SV40 "hybrid."