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Appl Environ Microbiol. 1968 June; 16(6): 835-840
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Stability of Suspensions of Influenza Virus Dried to Different Contents of Residual Moisture by Sublimation In Vacuo

Department of Pathology, Marquette School of Medicine, Inc., Milwaukee, Wisconsin 53233
Department of Pathology, Baptist Memorial Hospital, Memphis, Tennessee 38103
Department of Microbiology, The University of Tennessee School of Basic Medical Sciences, Memphis, Tennessee 38103

ABSTRACT

After freezing, suspensions of influenza virus were dried by sublimation of water in vacuo to contents of residual moisture of 3.2, 2.1, 1.7, 1, or 0.4%. The stability of the several suspensions was determined by an accelerated storage test. Based on the times predicted for the dried preparations stored at different temperatures to lose 1 log of infectivity titer, the order of stability in relation to residual moistures was as follows: 1.7% > 2.1% > 1% > 3.2% > 0.4%.