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Appl Environ Microbiol. 1968 May; 16(5): 777-780
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Turbidimetric Assays: the Antibiotic Dose-Response Line

Eli Lilly and Company, Indianapolis, Indiana 46206

ABSTRACT

Several antibiotics reduced growth of bacteria without killing them when present in the range of concentrations of significance in assaying. The reduction in growth rate was linearly related to concentration of antibiotic. From this fact may be derived an equation of the form log N = A - BC where N is the concentration of bacteria at the end of the incubation period, C is the concentration of antibiotic, and A and B are constants. This equation is used to guide the selection of the best range of concentrations of unknown for assay and to show the large influence of variations of temperature upon an assay.