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Appl Environ Microbiol. 1968 April; 16(4): 656-658
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Drug Resistance as Influenced by Inactivated Sensitivity Discs¹

Veterans Administration Hospital, Wilmington, Delaware 19805

ABSTRACT

Reports of staphylococci resistant to the semisynthetic penicillins stimulated a study of the factors influencing the stability of the drugs in discs. The behavior of penicillin G, methicillin, oxacillin, cloxacillin, and cephalothin discs under different humidity and temperature conditions is described. Humidity was found to be the most significant factor in drug inactivation. Storage of discs in a vacuum desiccator at -20 C provides maximal antibiotic stability.

² Present address: Veterans Administration Hospital, Batavia, N.Y.

¹ Completed as a project of a working group of the International Collaborative Study sponsored by the World Health Organization.