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Appl Environ Microbiol. 1968 April; 16(4): 582-587
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Antifungal Activity of Isothiocyanates and Related Compounds

III. Derivatives of Diphenyl, Stilbene, Azobenzene, and Several Polycondensed Aromatic Hydrocarbons

. Drobnica, M. Zemanová, P. Nemec, K. Anto, P. Kristián, A. Martvo and E. Závodská

Department of Microbiology and Biochemistry and Department of Organic Chemistry, Faculty of Chemistry, Slovak Polytechnical University, Bratislava
Department of Microbiology, Faculty of Natural Sciences, Komensk University, Bratislava
Institute of Organic Chemistry, Faculty of Natural Sciences, afárik University, Koice, Czechoslovakia

ABSTRACT

This paper presents the results of a study on the antifungal activity of isothiocyanates—derivatives of biphenyl (group "A"), of stilbene ("B"), of azobenzene and benzeneazonaphthalene ("C"), of naphthalene ("D"), and of further polycondensed aromatic hydrocarbons ("E"). From a total of 48 investigated compounds, antifungal activity was observed only in A and D group compounds. B, C, and E group derivatives are extremely insoluble in water, and the molecules are very large; as a result, they probably cannot pass into spores or mycelium of fungi. Thus, the —NCS group cannot manifest its reactivity.