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Appl Environ Microbiol. 1968 February; 16(2): 362-365
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Preservation of Influenza Virus Infectivity by Lyophilization

W. B. Beardmore, T. D. Clark and K. V. Jones

Research Laboratories, Parke-Davis and Co., Detroit, Michigan 48232

ABSTRACT

A method of lyophilizing influenza virus in allantoic fluid with retention of high-titer of egg infectivity is described. Five strains of virus were lyophilized, and all were much more stable than fluid virus preparations, retaining 2 to 3 logs of infectivity after storage at 37 C for 60 to 95 days. Statistical analysis of an accelerated storage test by extrapolation of viral degradation indicates that the lyophilized viruses are stable indefinitely at or below room temperature.

Appl Environ Microbiol. 1968 February; 16(2): 362-365
Copyright © 1968 American Society for Microbiology. All Rights Reserved.





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Copyright © 1968 by the American Society for Microbiology. All rights reserved.