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Appl Environ Microbiol. 1968 November; 16(11): 1761-1763
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Effect of Type of Red Blood Cells on Antistreptolysin O Titer

Streptococcus Unit, National Communicable Disease Center, Atlanta, Georgia 30333

ABSTRACT

Antistreptolysin O (ASO) titers were determined on 117 human sera with rabbit, human, and sheep red blood cells (RBC) as the indicator system in the ASO tube test. The titers of 65% of the sera were one dilution step higher when a 5% suspension of sheep RBC was used instead of a 5% suspension of rabbit RBC. Titers were one dilution step higher in 42.7% of the sera when a 5% suspension of human RBC was used instead of a 5% suspension of rabbit RBC. The best comparability of titers was between a 5% suspension of human RBC and a 2.5% suspension of sheep RBC.