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Appl Environ Microbiol. 1968 November; 16(11): 1719-1722
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Murine Toxicity of Cochliobolus carbonum¹

Research Triangle Institute, Research Triangle Park, North Carolina 27709
Department of Plant Pathology, North Carolina State University, Raleigh, North Carolina 27607

ABSTRACT

Seventeen wild-type strains of the phytopathogenic fungus Cochliobolus carbonum, tested by intraperitoneal injection into mice, were lethal within 48 hr. The lethal effect appeared to be a toxic rather than an infectious process, because death occurred within 3 hr after injection of two of the isolates and heat-killed cultures were lethal. Assays of ascospore progeny from two crosses involving three isolates indicated that the toxic metabolites were under genetic control and quantitative regulation. Studies of the toxicological, cultural, and chemical characteristics of these three strains indicated that more than one murine toxin was present.

² Present address: Department of Poultry Science, North Carolina State University, Raleigh, N.C. 27607.

³ Present address: Department of Plant Pathology, Pennsylvania State University, University Park, Pa. 16802.

¹ Paper 2585 of the Journal Series of the North Carolina State University Agricultural Experiment Station, Raleigh, N.C.