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Appl Environ Microbiol. 1968 January; 16(1): 69-72
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Continuous Production of Clostridium tetani Toxin

Bengt Zacharias and Marianne Björklund

Research Institute of National Defence, Sundbyberg 4, Sweden

ABSTRACT

The continuous production of Clostridium tetani toxin has been carried out in a 1-liter stirred culture vessel for as long as 65 days. Toxin production of approximately 120 flocculating units per ml was maintained with a dilution rate of 0.125 hr-1, a temperature of 34 C, a pH of 7.4, and the addition to the medium of 0.1 g of potassium chloride per liter. The average minimal lethal intraperitoneal dose of the toxin in mice was approximately 106 per ml.

Appl Environ Microbiol. 1968 January; 16(1): 69-72
Copyright © 1968 American Society for Microbiology. All Rights Reserved.





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Copyright © 1968 by the American Society for Microbiology. All rights reserved.