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Appl Environ Microbiol. 1967 November; 15(6): 1456-1459
Copyright © 1967 American Society for Microbiology. All Rights Reserved.

Inactivation of Venezuelan Equine Encephalomyelitis Virus by {gamma}-Radiation

Morton Reitman and Henry R. Tribble Jr.

Medical Sciences Laboratory and Biological Sciences Laboratory, Fort Detrick, Frederick, Maryland 21701

ABSTRACT

Exposure of Venezuelan equine encephalomyelitis (VEE) virus (at -70 C) to 6 x 106 r {gamma}-radiation (60Co) resulted in loss of lethality for young adult mice and guinea pigs, and loss of capacity to produce plaques or cytopathic effects in tissue culture. The suckling mouse was more sensitive for detecting live virus in radiated suspensions than was the adult mouse or guinea pig. Live virus was demonstrable in preparations exposed to 6 x 106 r but not in suspensions exposed to 8 x 106 r and more. The rate of inactivation of VEE virus by {gamma}-radiation was an exponential function of the dosage.

Appl Environ Microbiol. 1967 November; 15(6): 1456-1459
Copyright © 1967 American Society for Microbiology. All Rights Reserved.





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