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Appl Environ Microbiol. 1967 November; 15(6): 1452-1455
Copyright © 1967 American Society for Microbiology. All Rights Reserved.

Photodynamic Inactivation of Newcastle Disease Virus with Acridine Orange¹

Department of Microbiology and Preventive Medicine, School of Veterinary Medicine, University of Georgia Athens, Georgia 30602

ABSTRACT

Newcastle disease virus in allantoamnionic fluid was photosensitized with acridine orange, and then photodynamically inactivated. The inactivation rate was directly proportional to light intensity and to dye concentrations up to a level of approximately 100 to 200 µg/ml. Inactivation occurred at approximately an exponential rate for the first 4.5 log₁₀ units of virus, and then continued at a decreasing rate.

² Postdoctoral Fellow in Microbiology (National Institutes of Health Training Grant AI-197). Present address: National Animal Disease Laboratory, Ames, Iowa 50010.

¹ Paper No. 676 of the Institute of Comparative Medicine. Based on Ph.D. Thesis by the senior author.