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Appl Environ Microbiol. 1963 September; 11(5): 423-426

Bacterial Vaccine in Multidose Tablet Form for Parenteral Use

Department of Biologics Research, Division of Communicable Disease and Immunology, Walter Reed Army Institute of Research, Washington, D.C.

ABSTRACT

Dried typhoid vaccines were prepared by freeze-drying of heat-inactivated phenolized-cell suspensions and by an acetone-killed and dried technique. Portions of the dried powder obtained by each method were compressed into tablets. Tests with the products showed that drying and making of tablets did not affect the ability of the vaccines to protect mice or elicit antibodies in rabbits.

¹ Present address: U.S. Army Medical Unit, Fort Detrick, Frederick, Md.

² Present address: Pakistan-SEATO Cholera Research Laboratory, Dacca, East Pakistan.