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Appl Environ Microbiol. 1963 January; 11(1): 58-61

Nonbiological Conversion of Cephalosporin C to a New Antibiotic by Sodium Thiosulfate

A. L. Demain, Joanne F. Newkirk, G. E. Davis and R. E. Harman

Merck Sharp & Dohme Research Laboratories, Division of Merck & Co., Inc., Rahway, New Jersey

ABSTRACT

The apparent stimulation of cephalosporin C biosynthesis by sodium thiosulfate is due to a nonbiological conversion of cephalosporin C to a new derivative, cephalosporin Cx. The new compound is more active than cephalosporin C against the assay organism, Escherichia coli W-208. Cephalosporin Cx retains the properties of ultraviolet absorption and resistance to penicillinase, but migrates more slowly than cephalosporin C in the paper-chromatographic system used.

Appl Environ Microbiol. 1963 January; 11(1): 58-61






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