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Appl Environ Microbiol. 1962 July; 10(4): 321-325

Biosynthesis of Cephalosporin C

Arnold L. Demain and Joanne F. Newkirk

Merck Sharp & Dohme Research Laboratories, Division of Merck & Co., Inc., Rahway, New Jersey

ABSTRACT

The superiority of D-methionine over L-methionine for stimulation of cephalosporin C synthesis in a crude medium was confirmed. The optimal level of DL-methionine was 0.5%. Methionine stimulates growth slightly but this is not thought to be the cause of the marked stimulation of antibiotic synthesis. Of a large number of sulfur compounds tested, only DL-methionine-DL-sulfoxide and S-methyl-L-cysteine showed considerable methionine-replacing activity. Lysine and {alpha}-aminoadipic acid were inactive.

Appl Environ Microbiol. 1962 July; 10(4): 321-325






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