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Appl Environ Microbiol. 1962 July; 10(4): 293-296

Growth-Biosynthesis Relationships in Erythromycin Fermentation

R. L. Smith, H. R. Bungay and R. C. Pittenger

Eli Lilly and Company, Indianapolis, Indiana

ABSTRACT

The relationship of erythromycin biosynthesis to growth appears to vary with the fermentation medium in which the microorganism is grown. In a medium containing a complex nitrogen source, antibiotic production occurred only when growth was halted, whereas in a glycine-containing synthetic medium the two parameters increased at nearly the same time. An autostimulation of antibiotic production through addition of erythromycin is reported. Also described is the use of a labeled precursor as an index of biosynthesis rates during short periods of time.

Appl Environ Microbiol. 1962 July; 10(4): 293-296






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