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Appl Environ Microbiol. 1962 May; 10(3): 190-192

Analysis of Different Cell Systems for the Production of Attenuated Poliomyelitis Virus Vaccine

M. Balducci, R. Santoro, G. Mancini and D. Balducci

Department of Microbiology, Istituto Superiore di Sanità, Rome, Italy

ABSTRACT

The optimal cellular system to produce attenuated virus vaccine should have the following characteristics: ease and reproducibility of preparation, ability to produce virus at high titer, absence of latent viruses, and diploid chromosome complement.

At the present, primary monkey kidney is still the cellular system of choice but other systems appear to be promising.

Appl Environ Microbiol. 1962 May; 10(3): 190-192






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