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Appl Environ Microbiol. 1962 March; 10(2): 157-168

Studies on the Biosynthesis of Streptomycin

Institute of Microbiology, Rutgers, The State University, New Brunswick, New Jersey

ABSTRACT

Myo-inositol, especially in combination with arginine, enhances streptomycin production. Compounds which show structural relationship with myo-inositol are ineffective.

Myo-inositol decreases the incorporation of C¹⁴-glucose into streptomycin, particularly into streptidine. This effect suggests that myo-inositol is a precursor of the streptidine ring.

Methionine stimulates antibiotic production in a synthetic medium but proves to be unfavorable in a complex medium.

The - and -isomers of hexachlorocyclohexane inhibit streptomycin formation.

The formation of streptomycin by washed mycelium was studied. Essentially the same results were here obtained as with growing cultures.

¹ Chas. Pfizer postdoctoral fellow in microbiology; present address: Department of Biochemistry, Calcutta University, Calcutta, India.

² Supported in part by National Science Foundation grant G-13950; present address: Institut für Bakteriologie, Weihenstephan, Germany.