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Appl Environ Microbiol. 1962 January; 10(1): 55-59

Antibiotic Production by Anaerobic Bacteria¹

Pennsylvania State University, University Park, Pennsylvania

ABSTRACT

Soils from aerobic and anaerobic sources were investigated for the possible presence of bacteria which produce antibiotics under anaerobic conditions of growth. The screening techniques devised for this study yielded 157 soil bacteria which, during anaerobic growth, produced antibiotic activity against aerobic test bacteria.

Studies on choice of media, presence of oxygen, and changes in antibiotic activity during growth indicated that representative strains of these bacteria produced mixtures of antibiotics. The activity was heat labile.

¹ Authorized for publication on July 24, 1961, as paper no. 2580 in the journal series of the Pennsylvania Agricultural Experiment Station.